Pancreatic Neuroendocrine Tumor ( Net )

Neuroendocrine tumor

Neuroendocrine tumor (NET) are a relatively rare form of cancer. These cancer develops from cells which are capable of a number of hormones and to create to separate. Usually, but not always, this is a slow-growing cancer type.

These tumors occur in the neuro-endocrine system in the neuroendocrine cells. These cells are found in a variety of tissues in many places in the body. In .NET, these cells grow unrestrained, which may result in an excess of hormones and hormone-like substances. Through the blood hormones give signals that the operation of certain organs influence. By overproduction kinds of complaints may occur, such as diarrhea, "hot flashes, nausea and shortness of breath.


There may be many kinds prevent neuroendocrine tumor at various sites of the body, but most occur in the gastro-intestinal tract, the pancreas, and lungs. Carcinoids, for example, are a type of neuroendocrine tumors that often arise in the gastro-intestinal tract or the lungs. Another species, the pancreatic neuroendocrine tumor, sometimes referred to as tumors of the islets of Langerhans, are a few common type of neuroendocrine tumor. These pancreatic tumors can be difficult to treat if they are discovered in an advanced stage.
  • NET in the small intestine (carcinoid)
  • NET in the colon and rectum
  • NET in the cecum
  • NET in the stomach
  • NET in the pancreas
  • NET in the lung
  • NET in the liver


Neuroendocrine tumor are a relatively rare form of cancer, which receive annual camps only about five per 100,000 people. The incidence of neuroendocrine tumor, nevertheless significantly, and in the last thirty years, more than quadrupled. Individuals with a family history of cancer, and women with diabetes have an increased chance of developing a neuroendocrine tumor.

Neuroendocrine tumor symptoms

 These cancer develops from cells which are capable of a number of hormones and to create  Pancreatic Neuroendocrine Tumor ( NET )

Symptoms include associated with neuroendocrine tumors (but are not limited to):
  • flushing (hot flashes, flushes)
  • diarrhea
  • recurrent abdominal pain
  • wheezing
  • cough
  • bloody sputum
  • gastro-intestinal bleeding.
  • back pain
Some neuroendocrine tumor do not cause any symptoms. They sometimes come to light only when they have become so large that they press against other organs and therefore cause pain


Since the symptoms of this type of cancer in the early stages are often nonexistent or be confused with symptoms of other diseases, neuroendocrine tumor are often only detected at an advanced stage. For example, is estimated to be about 60% of the patients with pancreatic neuroendocrine tumor is already at an advanced stage of the disease at the time of the diagnosis.

There is no standard screening test for neuroendocrine tumor. Imaging techniques such as computed tomography (CT), magnetic resonance (NMR), echo-endoscopy and scintigraphy of somatostatin (a type of research that makes use of radionuclides) are indeed frequently used tools to diagnose neuroendocrine tumor. Blood and urine tests for biological markers, such as chromogranin A (CgA), or 5-hydroxy-indoleacetic acid (5-HIAA), a by-product of serotonin, to assess, is also used in the diagnosis of neuroendocrine tumors.

In some patients with neuroendocrine tumor can remain hidden for years if there are no clear or specific symptoms. In case of neuroendocrine tumor is the time span until the diagnosis estimated five to seven years. Even in patients with symptoms can be misdiagnosed as detected symptoms can mimic those of other diseases (eg, irritable bowel syndrome, ulcers, colitis, Crohn's disease).

Neuroendocrine tumor treatment

The treatment of neuroendocrine tumor is dependent on the size and location of the cancer, whether the cancer may or may not spread to other parts of the body and of the general state of health of the patient. The current therapeutic options include surgery, radiotherapy, chemotherapy and drug treatment.

In the Netherlands there are four specialized knowledge for .NET. Due to the rarity of NET treatment at a center highly recommended and beneficial to the quality of life for NET patients.

Patient organizations

The Belgian association NET & MEN Cancer will support patients and relatives who are faced with Neuroendocrine Tumors (NET) and Multiple Endocrine Neoplasia (MEN). The association NET & MEN Cancer will offer practical and psychosocial support through:
  • contacts between patients, family and loved ones achieve
  • organizing information and meeting days
  • giving information about the disease and how to deal with it.

She is also for:
  • visibility of NET & MEN
  • dissemination of knowledge about .NET & MEN to allow a correct diagnosis in time.

In the Netherlands, the Foundation NET group is active for people with neuroendocrine tumor (NET) and focuses on providing information about .NET, dissemination and brings patients into contact with each other. She also strives for more research into .NET.

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